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Common Side Effects of Mounjaro and How to Minimise Them

What is Mounjaro?

Mounjaro is a prescription medication used to treat type 2 diabetes and chronic weight management. It contains the active ingredient Tirzepatide, which mimics the effects of natural hormones that control blood sugar and appetite. By regulating these, Mounjaro helps reduce food intake and promotes a feeling of fullness. It is commonly prescribed to individuals with a BMI over 30 (obese) or those with a BMI over 27 (overweight) who have weight-related health issues.

Common Side Effects of Mounjaro

Like all medications, Mounjaro can cause side effects. Understanding these and knowing how to manage them can significantly improve your experience with the treatment.


 

Nausea and Vomiting

Nausea is one of the most frequently reported side effects of Mounjaro, often occurring in the first few weeks of treatment. This nausea may occasionally lead to vomiting.

Management Tips:

  • Take Mounjaro with food to help reduce nausea.
  • Stay hydrated by sipping water throughout the day.
  • Eat small, frequent meals instead of large ones.

 

Headaches

Some users of Mounjaro may experience headaches, which can vary in intensity.

Management Tips:

  • Ensure adequate hydration.
  • Rest in a quiet, dark room.
  • Over-the-counter pain relief, like paracetamol, may help, but consult your GP first.

 

Dizziness

Dizziness can occur when starting Mounjaro, especially as your body adjusts to the medication.

Management Tips:

  • Stand up slowly from sitting or lying positions.
  • Avoid driving if you feel dizzy.
  • Maintain regular meals to keep blood sugar levels stable.

 

Fatigue

Fatigue is another side effect that some individuals may experience.

Management Tips:

  • Prioritise rest and sleep.
  • Engage in light exercise to boost energy.
  • Maintain a balanced diet.

 

Dry Mouth

Dry mouth can be an uncomfortable side effect of Mounjaro.

Management Tips:

  • Drink plenty of water.
  • Chew sugar-free gum or suck on sugar-free sweets.
  • Avoid alcohol and caffeine.

 

Constipation

Constipation is a common side effect for some Mounjaro users.

Management Tips:

  • Increase your fibre intake with fruits, vegetables, and whole grains.
  • Drink plenty of water.
  • Stay physically active.

 

Diarrhoea

Conversely, some users may experience diarrhoea.

Management Tips:

  • Stay hydrated.
  • Avoid fatty, spicy, or high-fibre foods.
  • Consult your doctor if symptoms persist.

 

Insomnia

Insomnia or difficulty sleeping can affect overall health.

Management Tips:

  • Maintain a regular sleep routine.
  • Avoid stimulants like caffeine before bed.
  • Create a calm sleeping environment.

 

Increased Heart Rate

An increased heart rate is a less common side effect but should be monitored.

Management Tips:

  • Regularly monitor your heart rate.
  • Avoid strenuous activities.
  • Consult your healthcare provider if you notice significant changes.

 

Mood Changes

Mood changes including irritability or anxiety may occur.

Management Tips:

  • Practice stress-relief techniques.
  • Communicate with loved ones about your feelings.
  • Seek professional help if needed.

 

Side Effects Based on Mounjaro Dosage Escalation

The dosage of Mounjaro can affect the likelihood of side effects. The SURMOUNT-1 clinical trial found that gastrointestinal side effects were more common as the dosage increased:

  • 5 mg dose: 24.6% experienced nausea, 18.7% diarrhoea, 16.8% constipation, and 8.3% vomiting.
  • 10 mg dose: 33.3% experienced nausea, 21.2% diarrhoea, 17.1% constipation, and 10.7% vomiting.
  • 15 mg dose: 31.0% experienced nausea, 23.0% diarrhoea, 11.7% constipation, and 12.2% vomiting.

 

Serious Side Effects of Mounjaro


 

Pancreatitis

Pancreatitis is a serious condition involving inflammation of the pancreas. Symptoms include severe abdominal pain, vomiting, and fever.


 

Thyroid Tumours

There have been reports of thyroid tumours in patients taking Mounjaro. Symptoms may include a lump in the neck, difficulty swallowing, or shortness of breath.


 

Hypoglycaemia

Mounjaro may cause hypoglycaemia or low blood sugar. Symptoms include dizziness, sweating, confusion, and loss of consciousness.


 

Allergic Reactions

Severe allergic reactions, including anaphylaxis, require immediate medical attention.


 

Kidney Problems

Mounjaro can exacerbate kidney problems, especially in those with pre-existing conditions. Symptoms include changes in urine output and swelling.


 

Heart Problems

Cardiovascular events like heart attacks or strokes may occur. Immediate medical attention is essential if symptoms arise.


 

How to Minimise the Risk of Mounjaro Side Effects?

Start with a lower dose of Mounjaro, such as 2.5 mg per week, and gradually increase the dosage. Dietary and lifestyle changes, such as eating smaller meals and staying hydrated, can also help mitigate side effects.


 

When Should You Seek Professional Help?

Seek professional help if you experience severe side effects or symptoms of serious conditions like pancreatitis, thyroid tumours, or heart problems. At The Care Pharmacy, our healthcare providers can assist in managing side effects and optimising your treatment plan.


 

FAQs

  • How long do Mounjaro side effects last?
    Side effects typically last a few days to a couple of weeks.

  • How to minimise Mounjaro side effects?
    Start with a lower dose and gradually increase. Eat small, frequent meals.

  • How do you treat injection side reactions with Mounjaro?
    Use an ice pack on the injection site.

  • How long does Mounjaro stay in your system?
    Mounjaro has a half-life of about 5 days.

  • How to get Mounjaro out of your system fast?
    There is no way to expedite this process; your body needs time to metabolise the drug.

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